Sequential multiple assignment randomized trial trial#

Using a sequential multiple assignment randomized trial (SMART) to. We will demonstrate how SMARTs inform the development of high-quality adaptive interventions, discuss the research questions related to adaptive interventions that SMARTs can address, and offer considerations for designing SMARTs. Asher, Mary Burkhauser, Laura Mesite, and Diana Leyva. The second hour of this course is devoted to the sequential multiple assignment randomized trial (SMART). Sequential, Multiple Assignment, Randomized Trial Designs Research, Methods, Statistics JAMA JAMA Network.

In the first hour of this course, we introduce adaptive interventions including key elements of an adaptive intervention, contexts in which adaptive interventions are beneficial, and important considerations in the development of adaptive interventions. Sequential multiple assignment randomized trial (SMART) designs are applicable to clinical trials in which treatment decisions are guided by. Adaptive interventions provide a framework for practitioner decisions about whether, when, how and for whom to alter an intervention for best outcomes. Disease prevention and management interventions sometimes require adjustment based on individual response or changing needs during intervention. A sequential multiple assignment randomization trial (SMART)will be conducted to inform the development of an empirically based stepped care intervention that.